Cryptic crossword clue
Ann, seized by terrible clarity, becomes despotic 10

The most common and most likely answer to this crossword clue is the 10 letter word TYRANNICAL

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does TYRANNICAL mean?

TYRANNICAL adjective
  1. Of, or relating to tyranny or a tyrant.
  2. Despotic, oppressive or authoritarian.

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