Cryptic crossword clue
Annoyed? So issue direct rude remarks! 13

The most common and most likely answer to this crossword clue is the 13 letter word DISCOURTESIES

I've seen this crossword clue in Financial Times
D
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Buddy explains!

The straight part
We know that "rude remarks" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case rude remarks = discourtesies.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISCOURTESIES mean?

DISCOURTESIES noun
  1. Lack of courtesy; rudeness.
  2. A rude act.

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