The most common and most likely answer to this crossword clue is the 5 letter word VEXES
I've seen this crossword clue in Independent
V
E
X
E
S
More clues leading to the result VEXES
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does VEXES mean?
VEXES verb- To trouble aggressively, to harass.
- To annoy, irritate.
- To cause (mental) suffering to; to distress.
- To twist, to weave.
- To be irritated; to fret.
- To toss back and forth; to agitate; to disquiet.