Cryptic crossword clue
Annoys siblings, not last sister  7

The most common and most likely answer to this crossword clue is the 7 letter word BOTHERS

B
O
T
H
E
R
S

Buddy explains!

The straight part
We know that "Annoys" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case annoys = bothers.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BOTHERS mean?

BOTHERS noun
  1. Fuss, ado.
  2. Trouble, inconvenience.
BOTHERS verb
  1. To annoy, to disturb, to irritate.
  2. To feel care or anxiety; to make or take trouble; to be troublesome.
  3. To do something which is of negligible inconvenience.

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