The most common and most likely answer to this crossword clue is the 4 letter word ANEW
I've seen this crossword clue in The Times
A
N
E
W
More clues leading to the result ANEW
- Article we picked up again
- Answer recognised when heard again
- Article and novel together again
- Once more in decline, leader drops to last place
- Once again Shane Warne is hiding!
- Once again, Jane Wyman’s captivating
- Engaged in insane warfare again
- Once more with sheep – tails docked
- Flipping big city area taken over
- Once more or less good, Nixon’s vice-president
Buddy explains!

The straight part
We know that "again" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case again = anew.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ANEW mean?
ANEW adverb- Again, once more; afresh, in a new way, newly.