The most common and most likely answer to this crossword clue is the 9 letter word ANNOYANCE
I've seen this crossword clue in The Times
A
N
N
O
Y
A
N
C
E
More clues leading to the result ANNOYANCE
- Anyone can suspect pain
- Getting out of hand, can anyone bother?
- Pest spray can, anyone?
- Proclaim Russian character is replacing you, causing irritation
- Doctor anyone can hassle
- Article, canny one stirring anger
- Anyone can get upset, showing irritation
- Anyone can set out to cause a nuisance
- Can anyone get treatment for pain in the neck?
- Put crudely, can anyone bother?
Buddy explains!
The straight part
We know that "pain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pain = annoyance.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ANNOYANCE mean?
ANNOYANCE noun- That which annoys.
- An act or instance of annoying.
- The psychological state of being annoyed or irritated.