Cryptic crossword clue
Appearing in musical, perhaps men only in first number 2,5

The most common and most likely answer to this crossword clue is the 2 plus 5 letter word ON STAGE

I've seen this crossword clue in The Times
O
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Buddy explains!

The straight part
We know that "Appearing in musical, perhaps" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case appearing in musical, perhaps = on stage.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ON STAGE mean?

ON STAGE adjective
  1. On the part of a stage that is visible to the audience.
ON STAGE adverb
  1. Taking place on the part of a stage that is visible to the audience.

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