The most common and most likely answer to this crossword clue is the 7 letter word MOLLIFY
I've seen this crossword clue in The Guardian
M
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L
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More clues leading to the result MOLLIFY
Buddy explains!

The straight part
We know that "Appease" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case appease = mollify.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MOLLIFY mean?
MOLLIFY verb- To ease a burden, particularly worry; make less painful; to comfort.
- To appease (anger), pacify, gain the good will of.
- To soften; to make tender