Cryptic crossword clue
Apt to fret like a guitar tuned under the influence? 6,6

The most common and most likely answer to this crossword clue is the 6 plus 6 letter word HIGHLY STRUNG

H
I
G
H
L
Y
S
T
R
U
N
G

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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