The most common and most likely answer to this crossword clue is the 8 letter word TURN-OFF
I've seen this crossword clue in Financial Times
T
U
R
N
-
O
F
F
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TURN-OFF mean?
TURN-OFF noun- Something that repulses, disgusts, or discourages, especially sexually.
- A road where one turns off, such as a motorway exit.