The most common and most likely answer to this crossword clue is the 10 letter word HAMSTRINGS
I've seen this crossword clue in The Daily Telegraph
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More clues leading to the result HAMSTRINGS
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HAMSTRINGS mean?
HAMSTRINGS noun- One of the great tendons situated in each side of the ham, or space back of the knee, and connected with the muscles of the back of the thigh.
- The biceps femoris, semimembranosus, and semitendinosus muscles.
- To lame or disable by cutting the tendons of the ham or knee; to hough.
- To cripple; to incapacitate; to disable.