Cryptic crossword clue
Arranged date in Cairo means extermination 11

The most common and most likely answer to this crossword clue is the 11 letter word ERADICATION

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does ERADICATION mean?

ERADICATION noun
  1. The act of plucking up by the roots; an uprooting; extirpation; utter destruction.
  2. The state of being plucked up by the roots.

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