The most common and most likely answer to this crossword clue is the 4 plus 6 letter word LEFT HANDED
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LEFT HANDED mean?
LEFT HANDED noun- Left-handed people, taken as a whole.
- Using one's left hand in preference to, or more skillfully than, one's right.
- Intended to be worn on, or used by, the left hand.
- Turning or spiraling from right to left; anticlockwise.
- Awkward or maladroit.
- Insincere or malicious.
- Of magic, performed with the intention of doing harm, or for personal gain; evil or malevolent.
- Of a coordinate system: not following the right-hand rule.