The most common and most likely answer to this crossword clue is the 6 letter word RASHES
I've seen this crossword clue in Independent
R
A
S
H
E
S
Buddy explains!
The straight part
We know that "skin problems" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case skin problems = rashes.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does RASHES mean?
RASHES noun- An area of reddened, irritated, and inflamed skin.
- A surge in problems; a spate, string or trend.
- To prepare with haste.
- To pull off or pluck violently.
- To slash; to hack; to slice.