Cryptic crossword clue
As 22 across might be, by one German in 6, perhaps 6

The most common and most likely answer to this crossword clue is the 6 letter word REINED

I've seen this crossword clue in The Guardian
R
E
I
N
E
D

Buddy explains!

The straight part
We know that "As 22 across might be" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case as 22 across might be = reined.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REINED mean?

REINED verb
  1. To direct or stop a horse by using reins.
  2. To restrain; to control; to check.
  3. To obey directions given with the reins.

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