Cryptic crossword clue
Astonished with last of the beef being off? Take no chances 2,2,3,4,4

The most common and most likely answer to this crossword clue is the 2 plus 2 plus 3 plus 4 plus 4 letter word BE ON THE SAFE SIDE

I've seen this crossword clue in Independent
B
E
O
N
T
H
E
S
A
F
E
S
I
D
E

Buddy explains!

The straight part
We know that "Take no chances" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case take no chances = be on the safe side.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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