Cryptic crossword clue
Astute American company is supported by four in cut

The most common and most likely answer to this crossword clue is the 8 letter word INCISIVE

I
N
C
I
S
I
V
E

Buddy explains!

The straight part
We know that "Astute" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case astute = incisive.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INCISIVE mean?

INCISIVE adjective
  1. Quickly proceeding to judgment and forceful in expression; decisive; forthright.
  2. Intelligently analytical and concise.
  3. Having the quality of incising, cutting, or penetrating, as with a sharp instrument; sharp; acute; sarcastic; biting.
  4. Of or relating to the incisors.

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