Cryptic crossword clue
At heart Wagner, stricken by fear, worried persistently 6

The most common and most likely answer to this crossword clue is the 6 letter word GNAWED

G
N
A
W
E
D

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The straight part
We know that "worried persistently" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case worried persistently = gnawed.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GNAWED mean?

GNAWED verb
  1. To bite something persistently, especially something tough.
  2. To produce excessive anxiety or worry.
  3. To corrode; to fret away; to waste.

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