The most common and most likely answer to this crossword clue is the 6 letter word PANINI
I've seen this crossword clue in The Guardian
P
A
N
I
N
I
More clues leading to the result PANINI
- A lot of sudden anxiety about home baker’s product
- Grilled bread and roast at first attempt
- At home I sleep, rising to make a sandwich
- Find fault with small, not medium, snacks
- What cook uses, one eating popular Italian food
- These sandwiches may make you twist in pain
- Linguist’s sandwich
- Sandwiches: number in foreign bread set before one
- Dick bringing Nina back sandwiches from Italy
Buddy explains!

The straight part
We know that "a sandwich" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a sandwich = panini.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PANINI mean?
PANINI noun- A type of grilled sandwich made of a small loaf of bread, cut horizontally, filled with meat such as salami or ham, cheese or other food.