The most common and most likely answer to this crossword clue is the 2 plus 2 letter word IN RE
I
N
R
E
More clues leading to the result IN RE
- Prize picker not fully set up? That’s concerning
- Ultimate failure of one to pick Bond up is concerning
- Nitrogen in unopened pickle is concerning
- Touching up during summer nights
- Inadequacy of computer being set up is concerning
- Having free rein with regard to the matter
- Knight consumed by passion, touching
- Regarding restraint in getting promoted
- At the end, I pen Your Truelove as Regards
- Concerning the content of certain records
Buddy explains!

The straight part
We know that "as Regards" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case as regards = in re.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.