The most common and most likely answer to this crossword clue is the 8 letter word E-TAILER
I've seen this crossword clue in The Times
E
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T
A
I
L
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R
More clues leading to the result E-TAILER
Buddy explains!
The straight part
We know that "one who’d make a net profit?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one who’d make a net profit? = e-tailer.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does E-TAILER mean?
E-TAILER noun- A company that does business via electronic media, especially via the Internet