The most common and most likely answer to this crossword clue is the 6 plus 4 letter word POWDER PUFF
I've seen this crossword clue in The Times
P
O
W
D
E
R
P
U
F
F
Buddy explains!
The straight part
We know that "cosmetic applicator" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cosmetic applicator = powder puff.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.