The most common and most likely answer to this crossword clue is the 4 plus 6 letter word RIFT VALLEY
I've seen this crossword clue in The Daily Telegraph
R
I
F
T
V
A
L
L
E
Y
More clues leading to the result RIFT VALLEY
Buddy explains!
The straight part
We know that "depressed area in Africa" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case depressed area in africa = rift valley.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.