The most common and most likely answer to this crossword clue is the 6 letter word ESCHEW
I've seen this crossword clue in The Daily Telegraph
E
S
C
H
E
W
More clues leading to the result ESCHEW
- Refrain from having key cut
- Give up drugs with cocaine cut
- Pets regularly bite? Avoid!
- Avoid key getting cut
- Duck last couple of punches thrown by champ
- Shun champ after last of dope tests
- Avoid getting key cut
- Avoid extremes in encounters with champ
- Avoid small children in middle of freeway
- Avoid giving points to champ
Buddy explains!

The straight part
We know that "Avoid" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case avoid = eschew.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ESCHEW mean?
ESCHEW verb- To avoid; to shun, to shy away from.