Cryptic crossword clue
Awful moan that is indicating isolation and anxiety 6

The most common and most likely answer to this crossword clue is the 6 letter word ANOMIE

I've seen this crossword clue in The Guardian
A
N
O
M
I
E

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The straight part
We know that "isolation and anxiety" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case isolation and anxiety = anomie.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANOMIE mean?

ANOMIE noun
  1. Alienation or social instability caused by erosion of standards and values.

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