Cryptic crossword clue
Ax to grind with Barnaby’s brother George? 6

The most common and most likely answer to this crossword clue is the 6 letter word GRUDGE

G
R
U
D
G
E

Buddy explains!

The straight part
We know that "Ax to grind" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ax to grind = grudge.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GRUDGE mean?

GRUDGE noun
  1. Deep-seated and/or long-term animosity or ill will about something or someone, especially due to a past misdeed or mistreatment.
GRUDGE verb
  1. To be unwilling to give or allow (someone something).
  2. To grumble, complain; to be dissatisfied.
  3. To hold or harbour with malicious disposition or purpose; to cherish enviously.
  4. To feel compunction or grief.

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