Cryptic crossword clue
Babies 2 27, rears on noisome nappies 6

The most common and most likely answer to this crossword clue is the 6 letter word TINIES

I've seen this crossword clue in The Guardian
T
I
N
I
E
S

Buddy explains!

The straight part
We know that "Babies" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case babies = tinies.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TINIES mean?

TINIES noun
  1. A small child; an infant.
  2. Anything very small.

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