The most common and most likely answer to this crossword clue is the 5 letter word LOCUS
I've seen this crossword clue in The Guardian
L
O
C
U
S
More clues leading to the result LOCUS
- Look, America’s hiding carbon situation
- Certain place swarming grasshopper is finally eradicated
- Place mostly full of parasites to get caught in
- Place where a stripper briefly appears?
- Mostly in the dark about copper’s position
- Place American on mountain pass, returning
- Endless source of devastation in place
- Passage in book cut before point with page twice removed
- Back away from crazy American place
- Place where insect docked
Buddy explains!

The straight part
We know that "place" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case place = locus.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LOCUS mean?
LOCUS noun- A place or locality, especially a centre of activity or the scene of a crime.
- The set of all points whose coordinates satisfy a given equation or condition.
- A fixed position on a chromosome that may be occupied by one or more genes.
- (chiefly in the plural) A passage in writing, especially in a collection of ancient sacred writings arranged according to a theme.