Cryptic crossword clue
Bad headache from one rye, perhaps, consumed by me 8

The most common and most likely answer to this crossword clue is the 8 letter word MIGRAINE

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Buddy explains!

The straight part
We know that "Bad headache" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case bad headache = migraine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MIGRAINE mean?

MIGRAINE noun
  1. A severe, disabling headache, usually affecting only one side of the head, and often accompanied by nausea, vomiting, photophobia and visual disturbances.
  2. A neurological condition characterised by such headaches.

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