Cryptic crossword clue
Barrier in Ganges’ extremes has chalices 6

The most common and most likely answer to this crossword clue is the 6 letter word GRAILS

G
R
A
I
L
S

Buddy explains!

The straight part
We know that "chalices" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case chalices = grails.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GRAILS mean?

GRAILS noun
  1. The Holy Grail.
  2. The object of an extended or difficult quest.http//www.merriam-webster.com/dictionary/grail
GRAILS noun
  1. A book of offices in the Roman Catholic Church; a gradual.
GRAILS noun
  1. One of the small feathers of a hawk.

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