The most common and most likely answer to this crossword clue is the 6 letter word GUITAR
G
U
I
T
A
R
More clues leading to the result GUITAR
- Instrument leaders of group used in the auditorium rarely
- Pull back 27, briefly grabbing top of ice axe
- What’s instrumental in 9? Half of this publication’s about it
- Stop omitting intro in jazz piece, taking up instrument
- Barring margin pieces, played ligature in instrument
- Sentry stopped short holding it, stringed instrument
- Stringed instrument mostly good for Scottish sailor
- Instrument starts to generate useful information through automated reasoning
Buddy explains!

The straight part
We know that "instrument" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case instrument = guitar.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does GUITAR mean?
GUITAR noun- A stringed musical instrument, of European origin, usually with a fretted fingerboard and six strings, played with the fingers or a plectrum (guitar pick).
- Any type of musical instrument of the lute family, characterized by a flat back, along with a neck whose upper surface is in the same plane as the soundboard, with strings along the neck and parallel to the soundboard.
- To play the guitar.