Cryptic crossword clue
Be deceitful, getting into a state, causing estrangement 10

The most common and most likely answer to this crossword clue is the 10 letter word ALIENATION

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Buddy explains!

The straight part
We know that "estrangement" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case estrangement = alienation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ALIENATION mean?

ALIENATION noun
  1. The act of alienating.
  2. The state of being alienated.
  3. Emotional isolation or dissociation.
  4. Verfremdungseffekt.

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