The most common and most likely answer to this crossword clue is the 3 plus 3 plus 2 plus 1 plus 6 letter word GET ALL IN A LATHER
G
E
T
A
L
L
I
N
A
L
A
T
H
E
R
Buddy explains!
The straight part
We know that "Become agitated" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case become agitated = get all in a lather.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.