The most common and most likely answer to this crossword clue is the 4 plus 3 letter word LOSE ONE
I've seen this crossword clue in The Times
L
O
S
E
O
N
E
More clues leading to the result LOSE ONE
- Go wild in Revolutionary Paris?
- Become angry, so be unable to blow nose?
- Have kittens or seals gone swimming?
- See red and end up like a disgraced tabloid editor?
- General so so silly to get very angry
- Suffer maybe after dreadful Ofsted inspection and go crazy
- Find luggage missing but fail to get legal redress
Buddy explains!

The straight part
We know that "Become angry/so be unable to blow nose" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case become angry/so be unable to blow nose = lose one.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.