Cryptic crossword clue
Become dejected and react when Democrat replaces Republican 7

The most common and most likely answer to this crossword clue is the 7 letter word DESPOND

D
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The straight part
We know that "Become dejected" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case become dejected = despond.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DESPOND mean?

DESPOND noun
  1. Despondency.
DESPOND verb
  1. To give up the will, courage, or spirit; to become dejected, lose heart.

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