The most common and most likely answer to this crossword clue is the 6 letter word BUBBLE
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More clues leading to the result BUBBLE
Buddy explains!

The straight part
We know that "blister" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case blister = bubble.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does BUBBLE mean?
BUBBLE noun- A spherically contained volume of air or other gas, especially one made from soapy liquid.
- A small spherical cavity in a solid material.
- (by extension) Anything resembling a hollow sphere.
- Anything lacking firmness or solidity; a cheat or fraud; an empty project.
- A period of intense speculation in a market, causing prices to rise quickly to irrational levels as the metaphorical bubble expands, and then fall even more quickly as the bubble bursts.
- The emotional and/or physical atmosphere in which the subject is immersed.
- An officer's station in a prison dormitory, affording views on all sides.
- Someone who has been ‘bubbled’ or fooled; a dupe.
- A small, hollow, floating bead or globe, formerly used for testing the strength of spirits.
- The globule of air in the chamber of a spirit level.
- A laugh.
- A Greek.
- Any of the small magnetized areas that make up bubble memory.
- The point in a poker tournament when the last player without a prize loses all their chips and leaves the game, leaving only players that are going to win prizes. (e.g., if the last remaining 9 players win prizes, then the point when the 10th player leaves the tournament)
- A group of people who are in quarantine together.
- To produce bubbles, to rise up in bubbles (such as in foods cooking or liquids boiling).
- To churn or foment, as if wishing to rise to the surface.
- To rise through a medium or system, similar to the way that bubbles rise in liquid.
- To cheat, delude.
- To cry, weep.
- To pat a baby on the back so as to cause it to belch.
- To cause to feel as if bubbling or churning.
- To express in a bubbly or lively manner.
- To form into a protruding round shape.
- To cover with bubbles.
- To bubble in; to mark a response on a form by filling in a circular area (‘bubble’).