Cryptic crossword clue
Beginning to roll joints creates irritation 7

The most common and most likely answer to this crossword clue is the 7 letter word RANKLES

R
A
N
K
L
E
S

Buddy explains!

The straight part
We know that "creates irritation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case creates irritation = rankles.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RANKLES mean?

RANKLES verb
  1. To cause irritation or deep bitterness.
  2. To fester.

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