The most common and most likely answer to this crossword clue is the 12 letter word LORDÂ HELPÂ US
I've seen this crossword clue in The Guardian
L
O
R
D
Â
H
E
L
P
Â
U
S
Buddy explains!
The straight part
We know that "we’re in trouble" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case we’re in trouble = lord help us.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.