Cryptic crossword clue
Being gutless, meddle with Bowie’s arrangement 12

The most common and most likely answer to this crossword clue is the 12 letter word DISEMBOWELED

I've seen this crossword clue in The Guardian
D
I
S
E
M
B
O
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E
D

Buddy explains!

The straight part
We know that "gutless" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case gutless = disemboweled.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISEMBOWELED mean?

DISEMBOWELED verb
  1. To take or let out the bowels or interior parts of; to eviscerate.
  2. To take or draw from the body, as the web of a spider.

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