Cryptic crossword clue
Being unwell at home, Sid is upset with situation 13

The most common and most likely answer to this crossword clue is the 13 letter word INDISPOSITION

I
N
D
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S
P
O
S
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N

Buddy explains!

The straight part
We know that "Being unwell" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case being unwell = indisposition.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INDISPOSITION mean?

INDISPOSITION noun
  1. A mild illness, the state of being indisposed.
  2. A state of not being disposed to do something; disinclination; unwillingness.
  3. A bad mood or disposition.

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