Cryptic crossword clue
Beset with bad luck, Jack isn’t regularly cross with Edward 6

The most common and most likely answer to this crossword clue is the 6 letter word JINXED

I've seen this crossword clue in The Daily Telegraph
J
I
N
X
E
D

Buddy explains!

The straight part
We know that "Beset with bad luck" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case beset with bad luck = jinxed.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does JINXED mean?

JINXED verb
  1. To cast a spell on.
  2. To bring bad luck to.
  3. To cause something to happen by mentioning it, usually sarcastically.

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