The most common and most likely answer to this crossword clue is the 4 letter word PICK
I've seen this crossword clue in The Times
P
I
C
K
More clues leading to the result PICK
- Best shot last one of break
- Choice digging tool
- Choose a mountaineering accessory
- Choose something a miner would select?
- Single out that's groundbreaking?
- Note in contract for firing agent
- Select film that’s mentioned
- Select tool
- Choose to sleep around, caught making penetration
- Choose film with shock ending
Buddy explains!

The straight part
We know that "Best" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case best = pick.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PICK mean?
PICK noun- A tool used for digging; a pickaxe.
- A tool for unlocking a lock without the original key; a lock pick, picklock.
- A comb with long widely spaced teeth, for use with tightly curled hair.
- A choice; ability to choose.
- That which would be picked or chosen first; the best.
- A screen.
- An offensive tactic in which a player stands so as to block a defender from reaching a teammate.
- An interception.
- A good defensive play by an infielder.
- A pickoff.
- A tool used for strumming the strings of a guitar; a plectrum.
- A pointed hammer used for dressing millstones.
- A pike or spike; the sharp point fixed in the center of a buckler.
- A particle of ink or paper embedded in the hollow of a letter, filling up its face, and causing a spot on a printed sheet.
- That which is picked in, as with a pointed pencil, to correct an unevenness in a picture.
- The blow that drives the shuttle, used in calculating the speed of a loom (in picks per minute); hence, in describing the fineness of a fabric, a weft thread.
- To grasp and pull with the fingers or fingernails.
- To harvest a fruit or vegetable for consumption by removing it from the plant to which it is attached; to harvest an entire plant by removing it from the ground.
- To pull apart or away, especially with the fingers; to pluck.
- To take up; especially, to gather from here and there; to collect; to bring together.
- To remove something from somewhere with a pointed instrument, with the fingers, or with the teeth.
- To decide upon, from a set of options; to select.
- To seek (a fight or quarrel) where the opportunity arises.
- To recognise the type of ball being bowled by a bowler by studying the position of the hand and arm as the ball is released.
- To pluck the individual strings of a musical instrument or to play such an instrument.
- To open (a lock) with a wire, lock pick, etc.
- To eat slowly, sparingly, or by morsels; to nibble.
- To do anything fastidiously or carefully, or by attending to small things; to select something with care.
- To steal; to pilfer.
- To throw; to pitch.
- To peck at, as a bird with its beak; to strike at with anything pointed; to act upon with a pointed instrument; to pierce; to prick, as with a pin.
- To separate or open by means of a sharp point or points.
- To screen.