Cryptic crossword clue
Bet

The most common and most likely answer to this crossword clue is the 8 letter word PERFECTA

I've seen this crossword clue in Independent
P
E
R
F
E
C
T
A

Buddy explains!

The straight part
We know that "that’s 5 – American, originally (8)" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case that’s 5 – american, originally (8) = perfecta.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PERFECTA mean?

PERFECTA noun
  1. A kind of bet wherein the first and second-place finishers must be predicted in the correct order.

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