Cryptic crossword clue
Betrayal

The most common and most likely answer to this crossword clue is the 7 letter word TREASON

I've seen this crossword clue in Independent
T
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The straight part
We know that "of side in lost cause (7)" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case of side in lost cause (7) = treason.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TREASON mean?

TREASON noun
  1. The crime of betraying one’s own country.
  2. An act of treachery, betrayal of trust or confidence.

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