Cryptic crossword clue
Big cloud making one under the weather in part of London 6

The most common and most likely answer to this crossword clue is the 6 letter word BILLOW

I've seen this crossword clue in The Guardian
B
I
L
L
O
W

Buddy explains!

The straight part
We know that "Big cloud" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case big cloud = billow.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BILLOW mean?

BILLOW noun
  1. A large wave, swell, surge, or undulating mass of something, such as water, smoke, fabric or sound
BILLOW verb
  1. To surge or roll in billows.
  2. To swell out or bulge.

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