The most common and most likely answer to this crossword clue is the 6 letter word MEDINA
I've seen this crossword clue in The Daily Telegraph
M
E
D
I
N
A
More clues leading to the result MEDINA
- Holy city's name appearing in newspapers, etc.
- Racket during most of supper, maybe, in ancient quarter
- Big noise after this person comes to a holy city
- Fellows carrying little girl, coming to a holy city
- Antique quarter welcomed in African houses
- Large expanse of water in a holy city
- Muslim leader emerges first above pandemonium at a sacred city
- Maiden danced to city with The Gates' Mansion
- Uproar in Foreign Ministry about holy city
- Sources of news about northern Arabian city
Buddy explains!

The straight part
We know that "holy city" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case holy city = medina.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MEDINA mean?
MEDINA noun- The traditional, older or non-European area of a North African town.