Cryptic crossword clue
Big shots taking over peg out inconsequential people 8

The most common and most likely answer to this crossword clue is the 8 letter word NOBODIES

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Buddy explains!

The straight part
We know that "inconsequential people" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case inconsequential people = nobodies.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NOBODIES mean?

NOBODIES noun
  1. Someone who is not important or well-known.

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