Cryptic crossword clue
Big toe injured by Arthur, not Posh; it’s causing bone disease 14

The most common and most likely answer to this crossword clue is the 14 letter word OSTEOARTHRITIS

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Buddy explains!

The straight part
We know that "bone disease" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case bone disease = osteoarthritis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OSTEOARTHRITIS mean?

OSTEOARTHRITIS noun
  1. A form of arthritis, affecting mainly older people, caused by chronic degeneration of the cartilage and synovial membrane of the joints, leading to pain and stiffness.

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