Cryptic crossword clue
Big wheels left No 10 clutching millions 4

The most common and most likely answer to this crossword clue is the 4 letter word LIMO

I've seen this crossword clue in The Guardian
L
I
M
O


Buddy explains!

The straight part
We know that "Big wheels" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case big wheels = limo.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LIMO mean?

LIMO noun
  1. An automobile body with seats and permanent top like a coupe, and with the top projecting over the driver and a projecting front.
  2. An automobile with such a body.
  3. A luxury sedan or saloon car, especially one with a lengthened wheelbase or driven by a chauffeur.
  4. An automobile for transportation to or from an airport, including sedans, vans, and buses.

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