Cryptic crossword clue
Bilious woman needing some Kleenex I’ve passed over 5

The most common and most likely answer to this crossword clue is the 5 letter word VIXEN

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Buddy explains!

The straight part
We know that "Bilious woman" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case bilious woman = vixen.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VIXEN mean?

VIXEN noun
  1. A female fox.
  2. A malicious, quarrelsome or temperamental woman.
  3. A racy or salacious woman.
  4. A wife who has sex with other men with her husband's consent.

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